Statistical notes for clinical researchers: effect size
نویسنده
چکیده
328 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. In most clinical studies, p value is the final result of data analysis. A small p value is interpreted as a significant difference between the experimental group and the control group. However, reporting p value is not enough to know the actual difference. Problem of p value is that it depends on the sample size, n. Even a trivial meaningless difference can result in an extremely small p value when sample size is large. To make up this weak point, we need to report the 'effect size' as well as the p value. Effect size is a simple way to show the actual difference, which is independent of the sample size. In statistical testing we set a null hypothesis first and calculate the test statistic such as t values under an assumption of the null hypothesis. Finally, a p value is obtained which represents the probability of observing the current data due to chance when the null hypothesis is true. In most scientific articles, we usually make conclusion based on p values compared to the alpha error level chosen, e.g., 0.05. A smaller p value than alpha level is interpreted as a statistical significance. However, there are serious problems in relying on the p value only. First, depending on the sample size, a wide range of p values can be obtained with the same size of difference, which can lead to contradictory results: either statistically significant or insignificant conclusions. Examples 1 and 2 in Table 1 have the same trivial difference of 3 between before and after treatments, assuming a clinically meaningful difference as 10. Two results were contradictory: statistically significant (p = 0.001, Example 2) and insignificant (p = 0.382, Example 1) depending on whether the sample size is large (n = 10,000) or small (n = 100). Moreover, as appeared in Example 2, it is a serious problem that clinically meaningless condition is concluded as statistically significant. The treatment in example 2 is clinically insignificant but statistically significant! What would you reasonably conclude on this case? This is a problem caused by using inappropriately large sample sizes. Second, the information provided by the size of p value is confusing, because …
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عنوان ژورنال:
دوره 40 شماره
صفحات -
تاریخ انتشار 2015